|
|
|
|
|
| Desmarais, Erick; Belkhir, Khalid; Garza, John Carlos; Bonhomme, Francois. |
| Solitary LTR loci are the predominant form of LTR retrotransposons in most eukaryotic genomes. They originate from recombination between the two LTRs of an ancestral retrovirus and are therefore incapable of transposition. Despite this inactivity, they appear to have a substantial impact on the host genome. Here we use the murine RMER10 LTR family as an example to describe how such elements can reshape regions of the genome through multiple mutations on an evolutionary time scale. Specifically, we use phylogenetic analysis of multiple copies of RMER10 in rodent species, as well as comparisons of orthologous pairs in mouse and rat, to argue that insertions of members of this family have locally induced the emergence of tandem repeat loci as well as many... |
| Tipo: Text |
Palavras-chave: RMER10; Simple tandem repeats; LTR retrotransposons; Mouse genome. |
| Ano: 2006 |
URL: http://archimer.ifremer.fr/doc/2006/publication-2091.pdf |
| |
|
|
| Schmitt, Paulina; Gueguen, Yannick; Desmarais, Erick; Bachere, Evelyne; De Lorgeril, Julien. |
| Background: To gain insight into the molecular diversity of antimicrobial peptides and proteins in the oyster Crassostrea gigas, we characterized and compared the sequence polymorphism of the antimicrobial peptides (AMPs), Cg-Defensins (Cg-Defs) and Cg-Proline Rich peptide (Cg-Prp), and of the bactericidal permeability increasing protein, Cg-BPI. For that, we analyzed genomic and transcript sequences obtained by specific PCR amplification and in silico searches. Results: High diversification among the three antimicrobial effectors was evidenced by this polymorphism survey. On the basis of sequence phylogenies, each AMP aggregates into clearly defined groups of variants and is the product of a multigenic family displaying a variety of gene structures. In... |
| Tipo: Text |
|
| Ano: 2010 |
URL: http://archimer.ifremer.fr/doc/00001/11182/6691.pdf |
| |
|
|
|
